Long-term follow-up after quinacrine sterilization in Vietnam. Part I: interim efficacy analysis.

نویسندگان

  • D Sokal
  • D T Hieu
  • D H Weiner
  • D Q Vinh
  • T Huu Vach
  • R Hanenberg
چکیده

OBJECTIVE To determine the long-term efficacy of nonsurgical sterilization with quinacrine. DESIGN Observational cohort study. SETTING Rural provinces in northern Vietnam. PATIENT(S) Two thousand seven hundred and nine women who had quinacrine insertions between 1989 and 1993. INTERVENTION(S) Interviews in 1994, 1995, and 1996 and review of available medical records. Pregnancy rates were corrected for problems in detecting and confirming pregnancies. MAIN OUTCOME MEASURE(S) Pregnancy rates. RESULT(S) Over 90% of women were interviewed at least once. Uncorrected cumulative pregnancy rates were 12.9% at 5 y after two insertions and 27.3% after one insertion. Effectiveness varied by age group: the partially corrected pregnancy rates after two insertions were 6.8% in women 35 or older at the time of insertion and 13.0% in women under 35. A subgroup of women who received oral papaverine at the time of quinacrine insertion had lower pregnancy rates, with a cumulative uncorrected rate of 5.3% at 4 years among women of all ages. CONCLUSION(S) Efficacy of quinacrine appears reasonable for two insertions of quinacrine in women 35 and older. It may be possible to improve efficacy by the use of papaverine or the Hieu insertion technique.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Long-term follow-up after quinacrine sterilization in Vietnam. Part II: interim safety analysis.

OBJECTIVE To determine the long-term safety of nonsurgical sterilization with quinacrine. DESIGN Observational cohort study. SETTING Rural provinces in northern Vietnam. PATIENT(S) Two thousand eight hundred forty women who had had quinacrine insertions and an age-matched comparison group of 1,658 women who had an intrauterine device (IUD) insertion between 1989 and 1993. METHOD(S) Inte...

متن کامل

Association for Voluntary Surgical Contraception: a technical statement on quinacrine pellets for nonsurgical female sterilization.

For many years, researchers have been seeking nonsurgical methods for female sterilization because these methods may be safer, simpler, cheaper, and quicker than conventional techniques, and may require a lower level of skill to deliver. Various investigators have explored using intrauterine instillation of quinacrine for tubal occlusion. Until recently, reports of quinacrine use for nonsurgica...

متن کامل

What is the future for quinacrine sterilization?

The companion papers of Sokal and coworkers in the December 2000 issue of the journal describe their attempt through a retrospective survey to confirm the reported efficacy and safety of quinacrine sterilization in Vietnam (1, 2). Data presented on safety confirm the original report (3), although it should be noted that the risk of ectopic pregnancy will decline if efficacy improves over that o...

متن کامل

Four-year follow-up of insertion of quinacrine hydrochloride pellets as a means of nonsurgical female sterilization.

Eighty-four women were admitted to a study in Baroda, India, designed for evaluation of the efficacy of three transcervical insertions of quinacrine hydrochloride pellets, each 1 month apart, in producing occlusion of the oviducts. A 4-year follow-up has been completed for 100% of the women. Three women became pregnant during the time between the first and third administrations. Of the 81 women...

متن کامل

00 000 Quinacrine Sterilizations

100 000 quinacrine nonsurgical female sterilizations have been completed over the past decade involving transcervical insertion of quinacrine (252 mg) as pellets by one, two or three monthly insertions. No deaths have been reported and serious complications are far fewer than for surgical sterilization. Sideeffects are mild and transient. Efficacy has improved from 3 pregnancy failures per 100 ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Fertility and sterility

دوره 74 6  شماره 

صفحات  -

تاریخ انتشار 2000